Datingpoint ch test
Genes activated close to the source of Wnt production are called “short-range target” genes, whereas genes activated at longer distances from the Wnt-producing cells are recognized as “long-range target” genes.
The Wnt signaling is mostly silent during adult life.
: Concentration gradients formed by the lipid-modified morphogens of the Wnt family are known for their pivotal roles during embryogenesis and adult tissue homeostasis.
Wnt morphogens are also implicated in a variety of human diseases, especially cancer.
A better understanding of these essential cellular processes may have a great impact for development of therapies needed to combat cancer and other diseases in which Wnt signaling is involved.
Here, we outline recent advances in understanding of the Wnt secretion and spreading in polarized epithelia, and we particularly focus on the role of the lipid raft-associated reggie/flotillin proteins in these processes.
The collected experimental evidence for Wnt secretion indicates existence of specialized machineries for intracellular transport of Wnt proteins, discarding the idea of a passive flow of Wnts through the secretory pathway.